Republicans are retaining Senate seats in Tennessee, Mississippi, Maine and Oklahoma.
Lamar Alexander won a third-term in Tennessee after branding Democrat Gordon Ball as "one more vote for Barack Obama's agenda." In Oklahoma, Republican Sen. Jim Inhofe was re-elected, while Rep. James Lankford won the election to replace Republican Sen. Tom Coburn, who is resigning.
In Mississippi, Thad Cochran, who endured a tough primary, won re-election. And Susan Collins won a fourth Senate term from Maine.
Massachusetts Democrat Ed Markey and Democrat Cory Booker in New Jersey each won a first full term after winning special elections last year.
Earlier, Republicans picked up an additional Senate seat in West Virginia.
Tennessee voters re-elected Gov. Bill Haslam, while Republican Robert Bentley won a second term as governor of Alabama.
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